Capabilities and Services

Activery is offering a thermal analysis service for solid-state elucidation of organic or inorganic compounds. Compounds related to the chemical, polymer, cosmetics or pharmaceutical industry can be investigated. State-of-the-art instrumentation in form of a MDSC and MTGA is available.

If you want to externilize or simply improve your analytical performance through a solid state specialist as Activery contact us at:

dsc @activery.com or fill our web form, clicking here.

Thermal Analysis Service

Highlights of our instrument capabilities include:

DSC Q200

Tzero technology

Flat reproducible baselines, especially in the sub-ambient temperature range

Better signal-to-noise ratio with best available resolution

Absolute c_p measurement

Modulated DSC

Separation of complex transitions into easily interpretable components

Increased sensitivity for weak transitions with increased resolution without loss of sensitivity

Separation of reversing and non-reversing heat flow contribution

TGA Q500

Modulated TGA

Model free kinetic data

Calculation of activation energy

Improvement of industrial process productivity

High resolution TGA

Non linear heating rates

More accurate weight loss determination

Easier separation of multiple events

Our analytical staff combines more than 20 years of thermal analysis experience with compounds from the chemical and pharmaceutical industry. We offer fast sample turnaround and a favorable price structure for different kinds of experiments (price list available on request). Expert consultancy for thermal analysis problems is also available.

SELECTED APPLICATIONS

DSC (Differential Scanning Calorimetry)

Transition Temperatures

DSC provides rapid and precise determination of a variety of transition temperatures needing only a minimum amount of sample. Transition temperatures can be determined as well as resulting enthalpies (exothermic or endothermic). Measurable transitions include melting, glass transitions, crystallization, solid-solid transitions and mesophase transitions.

Polymorph Analysis

Pharmaceutical materials often exist in multiple crystal forms. These have the same chemical structure but a different crystalline structure which can result in significant differences in physical properties such as solubility, bioavailability and storage stability. DSC is the prevalent technique for the detection of polymorphism. Using heat-cool-heat techniques, the stability of various polymorphs can be identified and quantified.

Amorphous Solids and Crystallinity Quantification

Partially or completely amorphous solids exhibit a glass transition temperature and can exhibit a melt transition. Knowledge of glass transition temperatures is important for pharmaceutical stability storage and can be precisely determined with DSC. Changes in enthalpy of fusion detected by DSC, in comparison to a fully crystalline sample, can be used to determine the degree of crystallinity in an amorphous sample or vice versa.

TGA (Thermogravimetric Analysis)

Decomposition and Residues Analysis

Decomposition of organic materials and knowledge of eventual residue content is an important tool in product design and performance. Changes in decomposition temperature due to fillers or additives could be critical for the evaluation of new product candidates. High-resolution TGA allows the precise determination of decomposition temperatures and accurate quantification of residues after decomposition.

Volatiles Quantification

Determination of absorbed, bound or occluded moisture and organic volatiles is an important analysis for product performance. Further, pharmaceutical scientists routinely characterize the thermodynamic parameters of drug candidates including solvates and hydrates. TGA measurements allow rapid and precise determination of weight losses due to moisture or loss of crystal water.

Reaction Kinetics and Activation Energy

Knowledge of the kinetics of phase changes, conversions or decompositions is an important tool in assessing physical stability with temperature. Elucidation of conversion mechanisms is possible using the activation energy of the event. Modulated TGA provides not only the weight loss during the transition but also the associated activation energies in a single experiment.