Activery The amorphization specialist
Activery believes that amorphous drugs provide new and innovative routes to final dosage forms with differentiated pharmacokinetics
Activery believes that amorphous drugs provide new and innovative routes to final dosage forms with differentiated pharmacokinetics
SERVICE ANALYSE DSC ET TGA Activery offre aussi le service d analyse thermique (analyse DSC et TGA) en externalisation. Nous effectuons l analyse thermique pour différents produits chimies, polymères, cosmétiques et , spécialement, pour produits pharmaceutiques come des principes actives ou for...
In Activery we believe that solid state modifications may lead to a critical changes in your active pharmaceutical, thus to a differentiated drug or to a brand new innovative medicine
Activery possess unrivalled specialist expertise about different crystallization techniques and expert knowledge in the field of solid state modulation.
In Activery, we design and produce particles for special uses where size matters such as nanoparticles for cancer treatment. Through our technology you would enable new administration routes or renewed performance of your drug formulation.
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Statins: The World Market Report 2009-2024 from visionagain Report Details
Statins: The World Market, 2009-2024 provides a comprehensive analysis of the world statins market, compiled using a wealth of research tools - including interviews with key opinion-leaders, examination of commercial databases, company reports, policy documents, industry news and filings. This original study provides extensive sales forecasting, market shares present and future, informed opinion, as well as detailed analysis of unmet needs, pipeline developments and commercial opportunities for statin drugs. Highlights of Statins: The World Market, 2009-2024 include: With full market forecasts for all the major generic statins, this new visiongain report reveals the significant commercial opportunities in new sectors of the statin market. However, significant opportunities exist for original branded products too. With relatively few single statins currently in development, new product developments in statins will mainly focus on statin combination drugs, visiongain predicts. In addition, strong growth in the statins sector will occur in emerging national markets - most notably in China and India - driving global sales. There are vast and expanding existing and potential patient populations for those drugs worldwide. Table of Contents 1 Executive Summary 2 Dyslipidaemia and Coronary Heart Disease 2.1 Cholesterol and Triglycerides 2.2 Lipoproteins Transport Cholesterol and Triglycerides 2.3 Dyslipidaemia and Atherosclerosis 2.4 Cholesterol Risk Levels 2.5 The Fredrickson/World Health Organization (WHO) Classification of Dyslipidaemia 2.6 Cardiovascular Disease 2.7 CHD Risk Factors 2.8 Cholesterol Testing 2.9 Primary and Secondary Prevention of Atherosclerosis 3 Statins and Other Lipid-Lowering Drugs 3.1 Statins: Mechanism of Action and Types 3.2 Lovastatin 3.2.1 Lovastatin Indications 3.2.2 Lovastatin Brands and Generic Manufacturers 3.3 Simvastatin 3.3.1 Simvastatin Indications 3.3.2 Simvastatin Brands and Generic Manufacturers 3.4 Pravastatin 3.4.1 Pravastatin Indications 3.4.2 Pravastatin Brands and Generic Manufacturers 3.5 Fluvastatin 3.5.1 Fluvastatin Indications 3.5.2 Fluvastatin Brands and Generic Manufacturers 3.6 Atorvastatin 3.6.1 Atorvastatin Indications 3.6.2 Atorvastatin Brands and Generic Manufacturers 3.7 Rosuvastatin 3.7.1 Rosuvastatin Indications 3.7.2 Rosuvastatin Brands and Generic Manufacturers 3.8 Pitavastatin 3.9 Statin/Other Lipid-Lowering Drug Combinations 3.9.1 Lovastatin/Nicotinic Acid 3.9.2 Simvastatin/Nicotinic Acid 3.9.3 Simvastatin/Ezetimibe 3.9.4 Atorvastatin/Fenofibrate 3.9.5 Atorvastatin/Ezetimibe 3.9.6 Atorvastatin/Ezetimibe/Fenofibrate 3.10 Statin/Other Cardiovascular Drug Combinations 3.10.1 Caduet (Atorvastatin/Amlodipine) 3.10.2 Pravadual (Pravastatin/Aspirin) 3.10.3 Generic Statin/Other Cardiovascular Drugs 3.11 Other Dyslipidaemia Drugs 3.11.1 Anion-Exchange Resins 3.11.2 Ezetimibe 3.11.3 Fibrates 3.11.4 Nicotinic Acid 3.11.5 Omega-3-Acid Ethyl Esters 4 The World Statin Market 4.1 Statins Dominate the Lipid-Lowering Drug Market 4.1.1 The World Lipid-Lowering Drug Market 4.1.2 World Lipid-Lowering Drug Market Forecast, 2009-2024 4.2 The World Statin Market, 2009-2024 4.2.1 The World Statin Market, 2008 4.2.2 Scope for Further Growth: World Statin Market Forecast, 2009-2011 4.2.3 The Impact of Atorvastatin Genericisation on the World Statin Market, 2011-2014 4.2.4 Further Generic Opportunities: World Statin Market Forecast, 2014-2019 4.2.5 What are the Prospects for the World Statin Market from 2019 to 2024? 4.2.6 Statin Type Market Forecast, 2009-2024 4.3 The Branded and Generic Statin Markets 4.3.1 The Branded and Generic Statin Markets, 2008 4.3.2 By 2018 Sales of Generic Statins Will Exceed Branded Revenues 4.4 Atorvastatin 4.4.1 The Atorvastatin Market in 2008 4.4.2 Atorvastatin Market Forecast, 2009-2024 4.4.3 Lipitor Market Forecast, 2009-2011 4.4.4 The Ultimate Patent Cliff: Lipitor Market Forecast, 2011-2014 4.4.5 The Fate of Lipitor: Market Forecast, 2014-2024 4.4.6 Generic Atorvastatin Market Forecast, 2009-2024 4.5 Rosuvastatin 4.5.1 The Rosuvastatin Market in 2008 4.5.2 Rosuvastatin Market Forecast, 2009-2024 4.5.3 Bucking the Trend of Other Branded Statins: Crestor Market Forecast, 2009-2014 4.5.4 What are Crestor’s Prospects During 2014-2024? 4.5.5 Generic Rosuvastatin Market Forecast, 2009-2024 4.6 Simvastatin 4.6.1 The Simvastatin Market in 2008 4.6.2 Simvastatin Market Forecast, 2009-2024 4.6.3 Zocor Market Forecast, 2009-2024 4.6.4 Generic Simvastatin Market Forecast, 2009-2024 4.7 Pravastatin 4.7.1 The Pravastatin Market in 2008 4.7.2 Pravastatin Market Forecast, 2009-2024 4.7.3 Mevalotin/Pravachol Market Forecast, 2009-2024 4.7.4 Generic Pravastatin Market Forecast, 2009-2024 4.8 Fluvastatin 4.8.1 The Fluvastatin Market in 2008 4.8.2 Fluvastatin Market Forecast, 2009-2024 4.8.3 Lescol/Lochol Market Forecast, 2009-2024 4.8.4 Generic Pravastatin Market Forecast, 2009-2024 4.9 Pitavastatin 4.9.1 The Pitavastatin Market in 2008 4.9.2 Pitavastatin Market Forecast, 2009-2024 4.10 Lovastatin 4.10.1 The Lovastatin Market in 2008 4.10.2 Lovastatin Market Forecast, 2009-2024 4.11 Statin/Non-Statin Combination Drugs 4.11.1 The Statin/Non-Statin Combination Drug Market in 2008 4.11.2 Launch of new Statin Combination Drugs Will Drive Growth During 2009-2014 4.11.3 Genericisation in the Statin/Non-Statin Combination Sector, 2014-2024 4.11.4 Vytorin/Inegy Market Forecast, 2009-2013 4.11.5 Vytorin/Inegy Market Forecast, 2014-2024 4.11.6 Caduet Market Forecast, 2009-2024 4.12 Leading Statin Manufacturers 4.12.1 Leading Statin Manufacturers, 2008: Seven Players Control 85% of the Market 4.12.2 Pfizer’s Statin Revenues Forecast, 2009-2014 4.12.3 A New Leading Statin Manufacturer by 2013 4.12.4 Merck & Co./Schering-Plough Statin Revenues Forecast, 2009-2014 5 Issues Affecting the Statin Industry 5.1 SWOT Analysis of the Statin Industry 5.2 Patient Compliance 5.2.1 Patients on Statins Exhibit Poor Patient Compliance 5.2.2 Effective Contact Between Patients and Healthcare Practitioners is the Key to Improving Patient Compliance 5.2.3 Developments in Cholesterol Testing 5.2.4 Diagnostic Testing for Genetic Markers May Increase Patient Compliance 5.2.5 Increasing Use of Web-Based Information Technology Will Improve Patient Compliance 5.3 Generic Statins 5.3.1 Expected Patent Expiries in the Statin Market 5.3.2 Governments and Insurers Will Favour Generic Statins 5.4 Statin Clinical Trials 5.5 Safety of Statins 5.6 Statin OTC Switching 5.6.1 The Rationale for OTC Switching 5.6.2 Statin OTC Switching in the UK 5.6.3 Statin OTC Switching in the US 5.6.4 What are the Worldwide Prospects for Statin OTC Switching? 5.7 Prevalence of Coronary Heart Disease 5.7.1 Coronary Heart Disease is the Leading Cause of Death Worldwide 5.7.2 Future Projections for Prevalence of Coronary Heart Disease 5.7.3 The Economic Cost of Coronary Heart Disease 5.8 Promising Non-Statin Lipid-Lowering Pipeline 5.8.1 Statins Cannot Treat All Forms of Dyslipidaemia 5.8.2 Developments in Existing Rivals for Statins 5.8.2.1 Novel Nicotinic Acid Formulations 5.8.2.2 New Formulation of Fibrates 5.8.2.3 Omega-3 Fatty Acids 5.8.2.4 Functional Foods and Nutritional Supplements 5.8.3 Novel Lipid-Lowering Agents 5.8.3.1 CETP Inhibitors 5.8.3.2 Cholesterol Absorption Inhibitors 5.8.3.3 Antisense Oligonucleotides 5.8.3.4 PPAR-Alpha Agonists 5.8.3.5 MTP Inhibitors 5.8.3.6 Phospholipase A2 Inhibitors 5.8.3.7 Nicotinic Acid Receptor Agonists 5.8.3.8 Human Antibodies 6 Expert Opinion on Methods to Improve Patient Compliance 6.1 Statin Patient Compliance: Humayun J. Chaudhry, D.O., M.S., FACP, Commissioner of Health Services, Suffolk County, New York 6.1.1 Improving Patient Compliance in Statin Therapy 6.1.2 The Future of Cholesterol Testing 6.1.3 Web-Based Information Technology in Statin Prescribing 6.2 Genetic Markers to Improve Patient Compliance: Thomas White, Ph.D., Chief Scientific Officer and Vice President of Research and David P. Speechly, PhD Vice President Corporate Affairs, Celera 6.2.1 Patient Compliance for Statins is Poor 6.2.2 Genetic Markers: The KIF6 Risk Allele 6.2.3 Genetic Markers Could Improve Patient Compliance 6.2.4 Diagnostic Tests for Genetic Markers 6.2.5 Evidence for Genetic Marker Tests Increasing Patient Compliance 6.2.6 Effect of Genetic Marker Diagnostic Effects on Future Statin Prescribing Patterns 6.2.7 The Future of Cholesterol Testing 6.2.8 Effect of Genetic Markers on Clinical Trials Involving Statins 6.2.9 Web-Based Technologies to Improve Patient Compliance 7 Statin Country Markets 7.1 Leading Country Markets in 2008 7.2 Leading Country-Market Forecasts, 2009-2024 7.3 The US Statin Market 7.3.1 The US Statin Market in 2008 7.3.2 US Statin Market Forecast, 2009-2014 7.3.3 US Statin Market Forecast, 2014-2024 7.4 The Japanese Statin Market 7.4.1 The Japanese Statin Market in 2008 7.4.2 Japanese Statin Market Forecast, 2009-2024 7.5 The Canadian Statin Market 7.6 European Statin Markets 7.7 Emerging Statin Markets: China and India 8 The Statin Pipeline 8.1 The Statin Pipeline Lacks New Products 8.2 New Statins and Statin Combination Drugs in Development 8.2.1 Crestor/TriLipix 8.2.2 Crestor for Patients with Elevated CRP 8.2.3 Simvastatin and Nicotinic Acid/Laropiprant 8.2.4 Pravastatin and Fenofibrate Combination Therapy 8.2.5 Simvastatin and Fenofibrate Combination Therapy 8.2.6 Vytorin for Kidney Disease and Acute Coronary Syndrome. 8.2.7 Simvastatin/Rosiglitazone 8.2.8 PPD Statin/RBx 10558 8.2.9 Simvastatin/Aspirin/Lisinopril/Hydrochlorothiazide 8.2.10 Simvastatin/Aspirin/Ramipril 8.2.11 NCX 6560 8.2.12 Atorvastatin/Ezetimibe 9 Conclusions 9.1 The Statin Market in 2008 9.2 Future Challenges for the Statin Industry 9.3 Rise of the Generics: World Statin Market Forecast, 2009-2024 9.4 Leading Statin Manufacturers and Country Markets List of Tables Table 2.1 Risk Levels for Total Cholesterol Table 2.2 Risk Levels for LDL Cholesterol Table 2.3 Risk Levels for HDL Cholesterol Table 2.4 Risk Levels for Triglycerides Table 2.5 The Fredrickson/WHO Classification of Dyslipidaemia Table 3.1 Leading Generic Lovastatin Manufacturers Table 3.2 Leading Generic Simvastatin Manufacturers Table 3.3 Leading Generic Pravastatin Manufacturers Table 3.4 Branded Fibrates Table 3.5 Leading Prescription Omega-3 Acid Products Table 4.1 World Lipid-Lowering Drug Market, 2008 Table 4.2 Non-Statin Lipid-Lowering Drug Market, 2008 Table 4.3 World Lipid-Lowering Drug Market Forecasts, 2009-2014 Table 4.4 World Lipid-Lowering Drug Market Forecasts, 2015-2024 Table 4.5 Leading Statin Types and Brands, 2008 Table 4.6 Statin Type Market Forecasts, 2009-2014 Table 4.7 Statin Type Market Forecasts, 2015-2024 Table 4.8 The Branded and Generic Statin Markets, 2008 Table 4.9 Branded and Generic Statin Market Forecasts, 2009-2014 Table 4.10 Branded and Generic Statin Market Forecasts, 2015-2024 Table 4.11 Atorvastatin Market, 2008 Table 4.12 Atorvastatin Drugs Forecasts, 2009-2014 Table 4.13 Atorvastatin Drugs Forecasts, 2015-2024 Table 4.14 Rosuvastatin Market, 2008 Table 4.15 Rosuvastatin Drugs Forecasts, 2009-2014 Table 4.16 Rosuvastatin Drugs Forecasts, 2015-2024 Table 4.17 Simvastatin Market, 2008 Table 4.18 Simvastatin Drugs Forecasts, 2009-2014 Table 4.19 Simvastatin Drugs Forecasts, 2015-2024 Table 4.20 Pravastatin Market, 2008 Table 4.21 Pravastatin Drugs Forecasts, 2009-2014 Table 4.22 Pravastatin Drugs Forecasts, 2015-2024 Table 4.23 Fluvastatin Market, 2008 Table 4.24 Fluvastatin Drugs Forecasts, 2009-2014 Table 4.25 Fluvastatin Drugs Forecasts, 2015-2024 Table 4.26 Pitavastatin Drugs Forecasts, 2009-2014 Table 4.27 Pitavastatin Drugs Forecasts, 2015-2024 Table 4.28 Lovastatin Drugs Forecasts, 2009-2014 Table 4.29 Lovastatin Drugs Forecasts, 2015-2024 Table 4.30 Statin and Statin/Non-Statin Combination Drug Sales, 2008 Table 4.31 Statin/Non-Statin Combination Drug Market, 2008 Table 4.32 Statin/Non-Statin Combination Drugs Forecasts, 2009-2014 Table 4.33 Statin/Non-Statin Combination Drugs Forecasts, 2015-2024 Table 4.34 Leading Statin Manufacturers, 2008 Table 4.35 Leading Statin Manufacturers’ Revenue Forecasts, 2009-2014 Table 5.1 SWOT Chart for the Statins Industry, 2009-2024 Table 5.2 Expected Statin Patent Expiry Dates, 2009-2024 Table 5.3 Novel Lipid-Lowering Drugs in Development Table 7.1 Leading Statin Country Markets, 2008 Table 7.2 Leading Statin Country-Market Forecasts, 2009-2014 Table 7.3 Leading Statin Country Market Forecasts, 2015-2024 Table 8.1 The Statins Pipeline List of Figures Figure 4.1 World Lipid-Lowering Drug Market, 2008 Figure 4.2 World Lipid-Lowering Drug Market Forecast, 2009-2024 Figure 4.3 Statin Type Market Share, 2008 Figure 4.4 Leading Statin Brand Market Share, 2008 Figure 4.5 World Statin Market Forecast, 2009-2024 Figure 4.6 Statin Type Market Forecast, 2009-2024 Figure 4.7 Statin Type Market Share, 2014 Figure 4.8 Statin Type Market Share, 2019 Figure 4.9 Statin Type Market Share, 2024 Figure 4.10 Branded and Generic Statin Market Forecasts, 2009-2024 Figure 4.11 Atorvastatin Drugs Forecasts, 2009-2024 Figure 4.12 Rosuvastatin Drugs Forecasts, 2009-2024 Figure 4.13 Simvastatin Drugs Forecasts, 2009-2024 Figure 4.14 Pravastatin Drugs Forecasts, 2009-2024 Figure 4.15 Fluvastatin Drugs Forecasts, 2009-2024 Figure 4.16 Pitavastatin Drugs Forecasts, 2009-2024 Figure 4.17 Lovastatin Drugs Forecasts, 2009-2024 Figure 4.18 Statin Combination Drugs Forecasts, 2009-2024 Figure 4.19 Leading Statin Manufacturers, 2008 Figure 4.20 Leading Statin Manufacturers’ Revenue Forecasts, 2009-2014 Figure 7.1 Statin Market Share by Country, 2008 Figure 7.2 Statin Market Share by Country, 2014 Figure 7.3 Statin Market Share by Country, 2019 Figure 7.4 Statin Market Share by Country, 2024 Figure 7.5 US Statin Market Forecast, 2009-2024 Figure 7.6 Japanese Statin Market Forecast, 2009-2024 Figure 7.7 Canadian Statin Market Forecast, 2009-2024 Figure 7.8 French, UK, Chinese and Indian Statin Market Forecasts, 2009-2024 Figure 9.1 World Statin Market Forecast, 2009-2024 List of Organisations Mentioned in the Report Abbott Actavis Aegerion Almirall Alter [Spain] Amarin American Heart Association American Medical Association [US] Apotex Arena Pharmaceuticals [US] Astellas AstraZeneca Atherotech Bagó [Argentina] Bayer Berkeley HeartLab (part of Celera) BioInvent [Sweden] Bristol-Myers Squibb Celera Center for Cardiovascular Disease in Women at Brigham and Women's Hospital Centro Nacional de Investigaciones Cardiovasculares (National Centre for Cardiovascular Research, CNIC) [Spain] Chiesi Choongwae [South Korea] CINFA [Spain] Cobalt Laboratories Cobalt Pharmaceuticals Covidien Daiichi Sankyo Dr. Reddy's Laboratories European Medicines Agency (EMEA) European Society of Cardiology Ferrer Food and Drug Administration (FDA) Galephar Pharmaceutical Research Gedeon Richter Genentech Genfit Genzyme GlaxoSmithKline (GSK) Human Genome Sciences (HGS) Intas Isis Japan Tobacco Johnson & Johnson Kissei Kowa Krka Kyorin LifeCycle Pharma Liposcience Lupin Medicines and Healthcare products Regulatory Agency (MHRA) [UK] Medley [Brazil] Menarini Merck & Co. Merck/Schering-Plough Pharmaceuticals [joint venture between Merck & Co. and Schering-Plough] Micro Labs Mitsubishi Tanabe Mochida Mylan Nichi-Iko [Japan] NicOx Nissan Chemical Novartis Par Pfizer Pharmaceutical Product Development (PPD) Pierre Fabre Polpharma Public Citizen [US] Ranbaxy Ratiopharm Recordati Roche Sanofi-Aventis Sawai [Japan] Schering-Plough Sciele [wholly owned subsidiary of Shionogi] Sepracor Servier Shionogi Sigma Pharmaceuticals [Australia] Sigma-Tau SkyePharma Solvay Stada Teva University of Auckland Watson World Health Organization (WHO) Zentiva Zydus Cadila
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