Generation of re-dispersible nanoparticles is still a major challenge.

Most available’ bottom-up’ techniques (like supercritical fluid antisolvent techniques) produce heavily agglomerated masses of particles which do not break up on re-constitution, while ‘top-down’ methods such as milling are time consuming and often generate a substantially broad size distribution.

Additionally, high excipient loadings (e.g. 50-90 %) are frequently used with other technologies to ensure the generation of stable nanoparticles. The ASP Process (Atmospheric Supercritical Precipitation) is capable of producing nanoparticles with size ranges between 200-1000 nm which are easy to re-disperse in a suitable carrier.

Excipients such as polymers, surfactants or pH-regulators can be added if necessary or desired. Produced nanoparticles are recovered as fine dry powder providing intimate contact between active and possible excipients.