|
Brand Name(s)
|
Generic Name
|
Solid state
|
Sales 2006 (USD millions)
|
Change from 2005
|
Company(ies)
|
Disease/Medical Use
|
|
Lipitor
|
Atorvastatin
|
Non amorphous
|
14,385
|
7%
|
Pfizer, Astellas Pharma
|
Cholesterol
|
|
Advair, Seretide
|
Fluticasone + Salmeterol
|
Non amorphous
|
6,129
|
12%
|
GlaxoSmithKline
|
Asthma
|
|
Plavix, Iscover
|
Clopidogrel
|
Crystalline material
|
6,057
|
-5%
|
Bristol-Myers Squibb, Sanofi-Aventis
|
Thrombotic events
|
|
Nexium
|
Esomeprazole
|
Crystalline
|
5,182
|
12%
|
AstraZeneca
|
Gastrointestinal disorders
|
|
Norvasc
|
Amlodipine
|
Crystalline
|
4,866
|
3%
|
Pfizer
|
Hypertension
|
|
Remicade
|
Infliximab
|
Amorphous
|
4,428
|
23%
|
Johnson & Johnson, Schering-Plough, Tanabe
|
Rheumatoid arthritis
|
|
Enbrel
|
Etanercept
|
Amorphous
|
4,379
|
20%
|
Amgen, Wyeth
|
Rheumatoid arthritis
|
|
Zyprexa
|
Olanzapine
|
|
4,364
|
4%
|
Eli Lilly
|
Schizophrenia
|
|
Diovan
|
Valsartan
|
Amorphous drug
|
4,223
|
15%
|
Novartis
|
Hypertension
|
|
Risperdal
|
Risperidone
|
|
4,183
|
18%
|
Johnson & Johnson
|
Schizophrenia
|
|
Aranesp
|
Darbepoetin alfa
|
Amorphous
|
4,121
|
26%
|
Amgen
|
Anemia
|
|
Rituxan, MabThera
|
Rituximab
|
Amorphous
|
3,861
|
16%
|
Roche, Genentech, Biogen Idec, Chugai Pharmaceutical
|
Non-Hodgkin’s lymphoma
|
|
Effexor
|
Venlafaxine
|
Crystalline
|
3,722
|
8%
|
Wyeth
|
Depression, Anxiety disorders
|
|
Protonix, Pantozol, Pantoloc
|
Pantoprazole
|
Crystalline
|
3,621
|
4%
|
Wyeth, Altana, Solvay
|
Gastrointestinal disorders
|
|
Singulair
|
Montelukast
|
Crystalline
|
3,579
|
20%
|
Merck & Co.
|
Asthma
|
|
Seroquel
|
Quetiapine
|
Crystalline
|
3,560
|
23%
|
AstraZeneca, Astellas Pharma
|
Schizophrenia
|
|
Prevacid, Takepron
|
Lansoprazole
|
Crystalline
|
3,425
|
3%
|
TAP Pharmaceuticals, Takeda Pharmaceutical
|
Gastrointestinal disorders
|
|
Procrit, Eprex
|
Erythropoietin
|
Amorphous drug
|
3,180
|
-4%
|
Johnson & Johnson
|
Anemia
|
|
Cozaar, Hyzaar
|
Losartan
|
|
3,163
|
4%
|
Merck & Co.
|
Hypertension
|
|
Fosamax
|
Alendronate
|
|
3,134
|
-2%
|
Merck & Co.
|
Osteoporosis
|
|
Herceptin
|
Trastuzumab
|
Amorphous
|
3,134
|
83%
|
Roche, Genentech, Chugai Pharmaceutical
|
Breast cancer
|
|
Lovenox, Clexane
|
Enoxaparin
|
Amorphous
|
3,059
|
14%
|
Sanofi-Aventis
|
Deep-vein thrombosis
|
|
Avandia, Avandamet, Avandaryl
|
Rosiglitazone
|
Crystalline
|
3,043
|
26%
|
GlaxoSmithKline
|
Type 2 diabetes
|
|
Actos
|
Pioglitazone
|
Crystalline
|
2,880
|
25%
|
Takeda Pharmaceutical, Eli Lilly
|
Type 2 diabetes
|
|
Zocor
|
Simvastatin
|
Crystalline
|
2,803
|
-36%
|
Merck & Co.
|
Cholesterol
|
|
Copaxone
|
Glatiramer
|
Amorphous
|
2,757
|
19%
|
Teva Pharmaceutical Industries, Sanofi-Aventis
|
Multiple sclerosis
|
|
AcipHex, Pariet
|
Rabeprazole
|
Crystalline
|
2,729
|
-4%
|
Eisai, Johnson & Johnson
|
Gastrointestinal disorders
|
|
Neulasta
|
Filgrastim
|
Amorphous
|
2,710
|
18%
|
Amgen
|
Neutropenia
|
|
Lexapro, Cipralex
|
Escitalopram
|
Crystalline
|
2,696
|
16%
|
Forest Laboratories, H. Lundbeck
|
Depression, Anxiety disorders
|
|
Gleevec, Glivec
|
Imatinib
|
Non amorphous
|
2,554
|
18%
|
Novartis
|
Leukemia
|
|
Ambien, Stilnox
|
Zolpidem
|
Non amorphous
|
2,545
|
33%
|
Sanofi-Aventis
|
Insomnia
|
|
Aricept
|
Donepezil
|
Non amorphous
|
2,519
|
24%
|
Eisai, Pfizer
|
Alzheimer’s disease
|
|
Epogen
|
Erythropoietin
|
Amorphous
|
2,511
|
2%
|
Amgen
|
Anemia
|
|
Zyrtec, Cirrus
|
Cetirizine
|
Non amorphous
|
2,377
|
9%
|
Pfizer, UCB, Daiichi Sankyo
|
Allergic rhinitis
|
|
Avapro, Aprovel, Avalide
|
Irbesartan
|
Non amorphous
|
2,372
|
13%
|
Sanofi-Aventis, Bristol-Myers Squibb
|
Hypertension
|
|
Avastin
|
Bevacizumab
|
Amorphous
|
2,364
|
78%
|
Roche, Genentech
|
Colorectal cancer
|
|
Taxotere
|
Docetaxel
|
Amorphous
|
2,201
|
9%
|
Sanofi-Aventis
|
Cancer
|
|
Eloxatin, Eloxatine
|
Oxaliplatin
|
Amorphous
|
2,127
|
8%
|
Sanofi-Aventis
|
Colorectal cancer
|
|
Zoloft
|
Sertraline
|
Non amorphous
|
2,110
|
-35%
|
Pfizer
|
Depression, Anxiety disorders
|
|
Tamiflu
|
Oseltamivir
|
Non amorphous
|
2,096
|
69%
|
Roche, Chugai Pharmaceutical
|
Influenza
|
|
Lantus
|
Insulin analog
|
Amorphous
|
2,093
|
37%
|
Sanofi-Aventis
|
Type 2 diabetes and type 1 diabetes
|
|
Crestor
|
Rosuvastatin
|
Rosuvastatin calcium is a white amorphous powder
|
2,049
|
61%
|
AstraZeneca, Shionogi
|
Cholesterol
|
|
Humira
|
Adalimumab
|
Amorphous
|
2,044
|
46%
|
Abbott Laboratories
|
Rheumatoid arthritis
|
|
Celebrex
|
Celecoxib
|
Non amorphous
|
2,039
|
18%
|
Pfizer
|
Osteoarthritis and rheumatoid arthritis
|
|
Topamax
|
Topiramate
|
Non amorphous
|
2,027
|
21%
|
Johnson & Johnson
|
Seizures
|
|
Prevnar
|
vaccine
|
Amorphous
|
1,961
|
30%
|
Wyeth
|
Pneumococcal disease
|
|
Vytorin
|
Ezetimibe + Simvastatin
|
Non amorphous
|
1,955
|
90%
|
Merck & Co., Schering-Plough
|
Cholesterol
|
|
Zetia
|
Ezetimibe
|
Non amorphous
|
1,929
|
38%
|
Merck & Co., Schering-Plough
|
Cholesterol
|
|
Wellbutrin
|
Bupropion
|
Non amorphous
|
1,926
|
26%
|
GlaxoSmithKline, Biovail
|
Depression, Seasonal affective disorder (SAD)
|
|
Abilify
|
Aripiprazole
|
Crystalline
|
1,900
|
1%
|
Otsuka Pharmaceutical, Bristol-Myers Squibb
|
Schizophrenia
|
|
Lamictal
|
Lamotrigine
|
Crystalline
|
1,843
|
19%
|
GlaxoSmithKline
|
Seizures
|
|
Toprol, Seloken
|
Metoprolol
|
Crystalline
|
1,795
|
3%
|
AstraZeneca
|
Hypertension
|
|
NeoRecormon, Epogin
|
Erythropoietin
|
Amorphous
|
1,777
|
-1%
|
Roche, Chugai Pharmaceutical
|
Anemia
|
|
Atacand, Blopress
|
Candesartan
|
Cristalline
|
1,768
|
8%
|
Takeda Pharmaceutical, AstraZeneca
|
Hypertension
|
|
Spiriva
|
Tiotropium
|
Cristalline
|
1,735
|
45%
|
Boehringer Ingelheim
|
Chronic obstructive pulmonary disease
|
|
Avonex
|
Interferon beta-1a
|
Amorphous
|
1,707
|
11%
|
Biogen Idec
|
Multiple sclerosis
|
|
Viagra
|
Sildenafil
|
Crystalline
|
1,657
|
1%
|
Pfizer
|
Erectile dysfunction
|
|
Micardis
|
Telmisartan
|
Crystalline
|
1,645
|
35%
|
Boehringer Ingelheim, Astellas Pharma
|
Hypertension
|
|
Actonel
|
Risedronate
|
Crystalline
|
1,619
|
-4%
|
Procter & Gamble, Sanofi-Aventis
|
Osteoporosis
|
|
Lupron, Leuplin
|
Leuprolide
|
Amorphous
|
1,579
|
1%
|
Takeda Pharmaceutical, TAP Pharmaceuticals
|
Prostate cancer
|
|
TriCor, Lipanthyl
|
Fenofibrate
|
Amorphous
|
1,567
|
38%
|
Abbott Laboratories, Solvay
|
Cholesterol
|
|
Zofran
|
Ondansetron
|
Non amorphous
|
1,567
|
3%
|
GlaxoSmithKline
|
Nausea and vomiting
|
|
Valtrex
|
Valaciclovir
|
Non amorphous
|
1,563
|
24%
|
GlaxoSmithKline
|
Herpes
|
|
Levaquin, Floxin
|
Levofloxacin
|
Non amorphous
|
1,530
|
3%
|
Johnson & Johnson
|
Bacterial infections
|
|
Arimidex
|
Anastrozole
|
Non amorphous
|
1,508
|
28%
|
AstraZeneca
|
Breast cancer
|
|
Prograf
|
Tacrolimus
|
Non amorphous
|
1,499
|
20%
|
Astellas Pharma
|
Transplant rejection
|
|
CellCept
|
Mycophenolate mofetil
|
Non amorphous
|
1,470
|
8%
|
Roche, Chugai Pharmaceutical
|
Transplant rejection
|
|
Xalatan, Xalacom
|
Latanoprost
|
Non amorphous
|
1,453
|
6%
|
Pfizer
|
Intraocular pressure
|
|
Rebif
|
Interferon beta-1a
|
Amorphous
|
1,452
|
14%
|
Serono
|
Multiple sclerosis
|
|
Coreg
|
Carvedilol
|
Non amorphous
|
1,441
|
38%
|
GlaxoSmithKline
|
Hypertension
|
|
Gemzar
|
Gemcitabine
|
Non amorphous
|
1,408
|
5%
|
Eli Lilly
|
Cancer
|
|
Prilosec, Losec
|
Omeprazole
|
Non amorphous
|
1,371
|
-17%
|
AstraZeneca
|
Gastrointestinal disorders
|
|
Benicar, Olmetec
|
Olmesartan
|
Non amorphous
|
1,370
|
73%
|
Daiichi Sankyo, Forest Laboratories
|
Hypertension
|
|
Lotrel
|
Amlodipine + Benazepril
|
Non amorphous
|
1,352
|
26%
|
Novartis
|
Hypertension
|
|
Cymbalta
|
Duloxetine
|
Non amorphous
|
1,316
|
94%
|
Eli Lilly
|
Depression, Anxiety disorders
|
|
Imitrex, Imigran
|
Sumatriptan
|
Crystalline
|
1,315
|
4%
|
GlaxoSmithKline
|
Migraine
|
|
Depakote
|
Valproate semisodium
|
Crystalline
|
1,308
|
19%
|
Abbott Laboratories
|
Seizures
|
|
Humalog
|
Insulin analog
|
Crystalline
|
1,300
|
8%
|
Eli Lilly
|
Diabetes
|
|
Duragesic
|
Fentanyl
|
Crystalline
|
1,295
|
-18%
|
Johnson & Johnson
|
Pain
|
|
Pulmicort
|
Budesonide
|
Crystalline
|
1,292
|
11%
|
AstraZeneca
|
Asthma
|
|
Zometa
|
Zoledronate
|
Crystalline
|
1,283
|
5%
|
Novartis
|
Hypercalcemia
|
|
Betaseron, Betaferon
|
Interferon beta-1b
|
Amorphous
|
1,245
|
14%
|
Schering AG
|
Multiple sclerosis
|
|
Delix, Tritace
|
Ramipril
|
Crystalline
|
1,227
|
-3%
|
Sanofi-Aventis
|
Hypertension
|
|
Flovent, Flixotide
|
Fluticasone
|
Crystalline
|
1,219
|
5%
|
GlaxoSmithKline
|
Asthma
|
|
Neupogen
|
Filgrastim
|
Amorphous
|
1,213
|
0%
|
Amgen
|
Neutropenia
|
|
Casodex
|
Bicalutamide
|
Crystalline
|
1,206
|
7%
|
AstraZeneca
|
Prostate cancer
|
|
Pravachol
|
Pravastatin
|
Crystalline
|
1,197
|
-47%
|
Bristol-Myers Squibb
|
Cholesterol
|
|
Truvada
|
Tenofovir + Emtricitabine
|
Crystalline
|
1,194
|
110%
|
Gilead Sciences
|
HIV infection
|
|
Symbicort
|
Budesonide + Formoterol
|
Crystalline
|
1,184
|
18%
|
AstraZeneca
|
Asthma
|
|
Pegasys
|
Pegylated interferon alfa-2a
|
Amorphous
|
1,171
|
5%
|
Roche, Chugai Pharmaceutical
|
Hepatitis C
|
|
Evista
|
Raloxifene
|
Non-amorphous
|
1,159
|
4%
|
Eli Lilly, Chugai Pharmaceutical
|
Osteoporosis
|
|
Flomax
|
Tamsulosin
|
Crystalline
|
1,158
|
28%
|
Boehringer Ingelheim
|
Benign prostatic hypertrophy
|
|
Lyrica
|
Pregabalin
|
Crystalline
|
1,156
|
297%
|
Pfizer
|
Neuropathic pain
|
|
Paxil, Seroxat
|
Paroxetine
|
Crystalline
|
1,147
|
3%
|
GlaxoSmithKline
|
Depression, Anxiety disorders
|
|
Kaletra
|
Lopinavir
|
Crystalline
|
1,135
|
13%
|
Abbott Laboratories
|
HIV infection
|
|
Detrol
|
Tolterodine
|
Crystalline
|
1,100
|
11%
|
Pfizer
|
Overactive bladder
|
|
Harnal
|
Tamsulosin
|
Crystalline
|
1,085
|
-8%
|
Astellas Pharma
|
Benign prostatic hypertrophy
|
|
Erbitux
|
Cetuximab
|
Amorphous
|
1,075
|
56%
|
Bristol-Myers Squibb, Merck KGaA
|
Colorectal cancer
|
|
Synagis
|
Palivizumab
|
Amorphous
|
1,065
|
-9%
|
MedImmune
|
Respiratory syncytial virus
|
|
Augmentin
|
Co-amoxiclav
|
Crystalline
|
1,055
|
-13%
|
GlaxoSmithKline
|
Bacterial infections
|
|
Premarin, Prempro, Premphase
|
Estrogen
|
Crystalline
|
1,051
|
16%
|
Wyeth
|
Menopausal symptoms
|
|
Ortho contraceptives
|
Estrogen + Progesterone
|
Crystalline
|
1,016
|
-11%
|
Johnson & Johnson
|
Contraception
|
|
Zoladex
|
Goserelin
|
Amorphous
|
1,008
|
0%
|
AstraZeneca
|
Prostate cancer
|
|
Cerezyme
|
Imiglucerase
|
Amorphous
|
1,007
|
8%
|
Genzyme
|
Gaucher disease
|
|
Cravit
|
Levofloxacin
|
Crystalline
|
1,002
|
2%
|
Daiichi Sankyo, Santen Pharmaceutical
|
Bacterial infections
|
|
Yasmin
|
Drospirenone
|
Crystalline
|
998
|
36%
|
Schering AG
|
Prevention of pregnancy
|
|
Kogenate
|
Recombinant factor VIII
|
Amorphous
|
989
|
19%
|
Bayer
|
Hemophilia
|
|
Botox
|
Botulin toxin
|
Amorphous
|
982
|
18%
|
Allergan
|
Cervical dystonia
|
|
Lamisil
|
Terbinafine
|
Crystalline
|
978
|
-14%
|
Novartis
|
Fungal infections
|
|
Combivir
|
Lamivudine + Zidovudine
|
Crystalline
|
977
|
-8%
|
GlaxoSmithKline
|
HIV infection
|
|
Zosyn, Tazocin
|
Piperacillin
|
Crystalline
|
972
|
9%
|
Wyeth
|
Bacterial infections
|
|
Cialis
|
Tadalafil
|
Crystalline
|
971
|
30%
|
Lilly, Lilly Icos
|
Erectile dysfunction
|
|
Keppra
|
Levetiracetam
|
|
956
|
36%
|
UCB
|
Seizures
|
|
NovoSeven
|
Factor VII
|
Amorphous
|
948
|
11%
|
Novo Nordisk
|
Bleeding due to hemophilia
|
|
Infanrix, Pediarix
|
vaccine
|
Amorphous
|
945
|
21%
|
GlaxoSmithKline
|
Diphtheria, tetanus, and pertussis
|
|
Nasonex
|
Mometasone
|
Non-amorphous
|
944
|
28%
|
Schering-Plough
|
Allergic rhinitis
|
|
Reyataz
|
Atazanavir
|
Non-amorphous
|
931
|
34%
|
Bristol-Myers Squibb
|
HIV infection
|
|
Concerta
|
Methylphenidate
|
Non-amorphous
|
930
|
20%
|
Johnson & Johnson
|
Attention-deficit hyperactivity disorder
|
|
Humulin
|
Recombinant human insulin
|
Amorphous
|
925
|
-8%
|
Eli Lilly
|
Diabetes
|
|
Neoral, Sandimmun
|
Ciclosporin
|
Amorphous
|
918
|
-4%
|
Novartis
|
Transplant rejection
|
|
Sandostatin
|
Somatostatin
|
Amorphous
|
915
|
2%
|
Novartis
|
Acromegaly
|
|
Camptosar
|
Irinotecan
|
Amorphous
|
903
|
-1%
|
Pfizer
|
Colorectal cancer
|
|
Engerix-B, Havrix, Twinrix
|
vaccine
|
Amorphous
|
886
|
10%
|
GlaxoSmithKline
|
Hepatitis
|
|
Allegra, Telfast
|
Fexofenadine
|
Non-amorphous
|
864
|
-49%
|
Sanofi-Aventis
|
Allergic rhinitis
|
|
Adderall
|
Amphetamine
|
Non-amorphous
|
864
|
18%
|
Shire Pharmaceuticals
|
Attention-deficit hyperactivity disorder
|
|
Combivent
|
Ipratropium + Salbutamol
|
Non-amorphous
|
843
|
20%
|
Boehringer Ingelheim
|
Chronic obstructive pulmonary disease
|
|
Peg-Intron
|
Pegylated interferon alfa-2b
|
Amorphous
|
837
|
11%
|
Schering-Plough
|
Hepatitis C
|
|
Adalat
|
Nifedipine
|
Non-amorphous
|
825
|
0%
|
Bayer
|
Hypertension
|
|
Avelox, Avalox
|
Moxifloxacin
|
Non-amorphous
|
822
|
17%
|
Bayer, Schering-Plough, Shionogi
|
Bacterial infections
|
|
Mobic
|
Meloxicam
|
Non-amorphous
|
818
|
-66%
|
Boehringer Ingelheim, Daiichi Sankyo
|
Osteoarthritis and rheumatoid arthritis
|
|
Biaxin
|
Clarithromycin
|
Non-amorphous
|
816
|
-23%
|
Abbott Laboratories
|
Bacterial infections
|
|
Mevalotin
|
Pravastatin
|
Non-amorphous
|
799
|
-35%
|
Daiichi Sankyo
|
Cholesterol
|
|
Ultane, Sevorane
|
Sevoflurane
|
Amorphous
|
799
|
-9%
|
Abbott Laboratories
|
Anesthesia
|
|
Genotropin
|
Somatropin
|
Amorphous
|
795
|
-2%
|
Pfizer
|
Growth failure
|
|
Sustiva
|
Efavirenz
|
Crystalline
|
791
|
16%
|
Bristol-Myers Squibb
|
HIV infection
|
|
Zyvox
|
Linezolid
|
Crystalline
|
782
|
27%
|
Pfizer
|
Bacterial infections
|
|
Xeloda
|
Capecitabine
|
Crystalline
|
775
|
22%
|
Roche, Chugai Pharmaceutical
|
Cancer
|
|
Geodon, Zeldox
|
Ziprasidone
|
Crystalline
|
758
|
29%
|
Pfizer
|
Schizophrenia
|
|
Cipro, Ciprobay
|
Ciprofloxacin
|
Crystalline
|
755
|
-6%
|
Bayer, Schering-Plough
|
Bacterial infections
|
|
Provigil
|
Modafinil
|
Crystalline
|
735
|
43%
|
Cephalon
|
Sleepiness
|
|
Lescol
|
Fluvastatin
|
Crystalline
|
725
|
-5%
|
Novartis
|
Cholesterol
|
|
Clarinex, Aerius
|
Desloratadine
|
Crystalline
|
722
|
12%
|
Schering-Plough
|
Allergic rhinitis
|
|
Femara
|
Letrozole
|
Crystalline
|
722
|
35%
|
Novartis, Chugai Pharmaceutical
|
Breast cancer
|
|
Trileptal
|
Oxcarbazepine
|
Crystalline
|
721
|
17%
|
Novartis
|
Seizures
|
|
Tracleer
|
Bosentan
|
|
717
|
42%
|
Actelion
|
Pulmonary arterial hypertension
|
|
Primaxin
|
Imipenem + Cilastatin
|
Amorphous
|
705
|
-5%
|
Merck & Co.
|
Bacterial infections
|
|
Temodar
|
Temozolomide
|
Crystalline
|
703
|
20%
|
Schering-Plough
|
Anaplastic astrocytoma
|
|
Trusopt, Cosopt
|
Dorzolamide
|
Crystalline
|
697
|
13%
|
Merck & Co.
|
Intraocular pressure
|
|
Voltaren
|
Diclofenac
|
Crystalline
|
690
|
0%
|
Novartis
|
Osteoarthritis and rheumatoid arthritis
|
|
Viread
|
Tenofovir
|
Crystalline
|
689
|
-12%
|
Gilead Sciences
|
HIV infection
|
|
Sifrol
|
Pramipexole
|
Crystalline
|
673
|
23%
|
Boehringer Ingelheim
|
Parkinson’s disease
|
|
Namenda
|
Memantine
|
Crystalline
|
660
|
30%
|
Forest Laboratories
|
Alzheimer disease
|
|
Altace
|
Ramipril
|
Crystalline
|
653
|
18%
|
King Pharmaceuticals
|
Cardiovascular events
|
|
Byetta
|
Exenatide
|
Amorphous
|
649
|
464%
|
Amylin Pharmaceuticals, Eli Lilly
|
Type 2 diabetes
|
|
Tarceva
|
Erlotinib
|
Crystalline
|
649
|
110%
|
Roche, Genentech
|
Non-small cell lung cancer
|
|
Zithromax, Zmax
|
Azithromycin
|
Crystalline
|
638
|
-68%
|
Pfizer
|
Bacterial infections
|
|
Omnicef
|
Cefdinir
|
Amorphous
|
637
|
29%
|
Abbott Laboratories
|
Bacterial infections
|
|
Proscar
|
Finasteride
|
Crystalline
|
619
|
-16%
|
Merck & Co.
|
Benign prostatic hypertrophy
|
|
Alimta
|
Pemetrexed
|
Amorphous
|
612
|
32%
|
Eli Lilly
|
Non-small cell lung cancer
|
|
Merrem
|
Meropenem
|
|
604
|
20%
|
AstraZeneca
|
Bacterial infections
|
|
Forteo
|
Teriparatide
|
Amorphous
|
594
|
53%
|
Eli Lilly
|
Osteoporosis
|
|
Strattera
|
Atomoxetine
|
Crystalline
|
579
|
5%
|
Eli Lilly
|
Attention-deficit hyperactivity disorder
|
|
Actiq
|
Fentanyl
|
Crystalline
|
578
|
40%
|
Cephalon
|
Cancer pain
|
|
Flonase, Flixonase
|
Fluticasone
|
Crystalline
|
575
|
-52%
|
GlaxoSmithKline
|
Allergic rhinitis
|
|
Amaryl
|
Glimepiride
|
Crystalline
|
567
|
-33%
|
Sanofi-Aventis
|
Type 2 diabetes
|
|
Lidoderm
|
Lidocaine
|
Amorphous
|
567
|
35%
|
Endo Pharmaceuticals
|
Pain
|
|
Lunesta
|
Eszopiclone
|
Non amorphous
|
567
|
72%
|
Sepracor
|
Insomnia
|
|
Boniva, Bonviva
|
Ibandronate
|
Non amorphous
|
565
|
454%
|
Roche, GlaxoSmithKline
|
Osteoporosis
|
|
Taxol
|
Paclitaxel
|
Amorphous
|
563
|
-25%
|
Bristol-Myers Squibb
|
Cancer
|
|
Zelnorm, Zelmac
|
Tegaserod
|
Non amorphous
|
561
|
34%
|
Novartis
|
Irritable bowel syndrome
|
|
Renagel
|
Sevelamer
|
Non amorphous
|
559
|
23%
|
Genzyme, Roche, Chugai Pharmaceutical
|
Hyperphosphatemia
|
|
Norditropin
|
Human growth hormone
|
Amorphous
|
557
|
19%
|
Novo Nordisk
|
Growth hormone deficiency
|
|
Xopenex
|
Levalbuterol
|
Non amorphous
|
555
|
29%
|
Sepracor
|
Bronchospasm
|
|
Xenical
|
Orlistat
|
Non amorphous
|
553
|
9%
|
Roche
|
Obesity
|
|
Vasotec, Vaseretic
|
Enalapril
|
Non amorphous
|
547
|
-12%
|
Merck & Co.
|
Hypertension
|
|
Serevent
|
Salmeterol
|
Non amorphous
|
538
|
-10%
|
GlaxoSmithKline
|
Asthma
|
|
Cardura
|
Doxazosin
|
Non amorphous
|
538
|
-8%
|
Pfizer
|
Hypertension
|
|
Synthroid
|
Levothyroxine
|
Non amorphous
|
534
|
-4%
|
Abbott Laboratories
|
Hypothyroidism
|
|
Gonal-f
|
Follitropin alfa
|
Amorphous
|
533
|
-3%
|
Serono
|
Infertility
|
|
Gaster
|
Famotidine
|
|
532
|
-10%
|
Astellas Pharma
|
Gastrointestinal disorders
|
|
Cancidas
|
Caspofungin
|
Amorphous
|
530
|
-7%
|
Merck & Co.
|
Fungal infections
|
|
Exelon
|
Rivastigmine
|
Non amorphous
|
525
|
12%
|
Novartis
|
Alzheimer’s disease
|
|
Vfend
|
Voriconazole
|
Non amorphous
|
515
|
30%
|
Pfizer
|
Fungal infections
|
|
Amlodin
|
Amlodipine
|
Non amorphous
|
506
|
4%
|
Dainippon Sumitomo
|
Hypertension, angina pectoris
|
|
Niaspan
|
Niacin
|
Non amorphous
|
498
|
13%
|
Kos Pharmaceuticals
|
Cholesterol
|
|
Neurontin
|
Gabapentin
|
Non amorphous
|
496
|
-22%
|
Pfizer
|
Seizures
|
|
Trizivir
|
Abacavir + Lamivudine + Zidovudine
|
Non amorphous
|
496
|
-10%
|
GlaxoSmithKline
|
HIV infection
|
|
Requip
|
Ropinirole
|
Non amorphous
|
496
|
74%
|
GlaxoSmithKline
|
Parkinson disease
|
|
Follistim, Puregon
|
Follitropin beta
|
Amorphous
|
482
|
8%
|
Akzo Nobel
|
Infertility
|
|
Basen
|
Voglibose
|
Non amorphous
|
476
|
-13%
|
Takeda Pharmaceutical
|
Hyperglycemia
|
|
Levitra
|
Vardenafil
|
Non amorphous
|
474
|
19%
|
Bayer, GlaxoSmithKline
|
Erectile dysfunction
|
|
Glucophage
|
Metformin
|
Non amorphous
|
459
|
-16%
|
Merck KGaA, Bristol-Myers Squibb
|
Type 2 diabetes
|
|
Concor
|
Bisoprolol
|
Non amorphous
|
455
|
4%
|
Merck KGaA
|
Hypertension
|
|
Epzicom, Kixeva
|
Abacavir + Lamivudine
|
Non amorphous
|
446
|
107%
|
GlaxoSmithKline
|
HIV infection
|
|
Xatral
|
Alfuzosin
|
Crystalline
|
443
|
8%
|
Sanofi-Aventis
|
Benign prostatic hypertrophy
|
|
Diflucan
|
Fluconazole
|
Crystalline
|
435
|
-13%
|
Pfizer
|
Fungal infections
|
|
Thalomid
|
Thalidomide
|
Crystalline
|
433
|
12%
|
Celgene
|
Erythema nodosum leprosum
|
|
Zantac
|
Ranitidine
|
Crystalline
|
429
|
-18%
|
GlaxoSmithKline
|
Gastrointestinal disorders
|
|
Xolair
|
Omalizumab
|
Amorphous
|
429
|
32%
|
Roche, Genentech
|
Asthma
|
|
Claritin
|
Loratadine
|
Crystalline
|
418
|
-5%
|
Schering-Plough, Shionogi & Co.
|
Allergic rhinitis
|
|
