Activery The amorphization specialist
Activery believes that amorphous drugs provide new and innovative routes to final dosage forms with differentiated pharmacokinetics
| ASP Atmospheric Supercritical Precipitation |
 |
 |
 |
| ASP: a new and versatile process to produce amorphous and crystallilne particles (micro & nanoparticles) In the ASP process, the CO2 is supplied as a turbulent jet exiting through a narrow orifice into the precipitation vessel. The drug solution is mixed isothermally and isobarically (at atmospheric pressure) with the CO2 jet inside the precipitation vessel by means of a tube with narrow inner diameter. Mixing initiates droplet formation and evaporation of the liquid. Liquid evaporation leads to nucleation and precipitation of the drug. During precipitation, the droplet continuously shrinks until it is completely evaporated. The precipitated drug powder is captured with a suitable filtration device and recovered as dry particles at the end of the precipitation. |
Pharma Notes
- New study on Inhaled Drug Delivery Market
- Particles that deliver larger and more effective doses of drugs to cancers
- The global protein therapeutics market will be worth $77bn by 2011 with biogenerics playing an increasingly important rol
- A federal jury in Texas Monday upheld the patent on Johnson & Johnson's arthritis treatment Remicade and ordered Abbott Laboratories to pay its rival $1.67 billion for infringing on the patent
- Transdermal delivery represents an attractive alternative to oral delivery of drugs and is poised to provide an alternative to hypodermic injection tool
Differentiated Generics
- Teva may lose patent challenge
- Labopharm receives notice of ANDA submission with paragraph IV certification for generic of Ryzolt
- Depomed (DEPO) Receives Paragraph IV Notice from Lupin Limited Over Patent Filing for Generic Glumetza Tablets
- The rate and number of successful Paragraph IV challenges is reducing the average effective patent life for innovator drugs
- Teva Sues Mylan Over Multiple Sclerosis Drug COPAXONE
Nanoparticles world
- Nanoparticle created to attack cardiovascular plaque
- Nanoparticle lung threat blocked
- Newly-developed nanoparticle to build therapies for treating individuals with cardiovascular disease.
- Nanoparticle Processing in the Solid State Dramatically Increases the Cell Membrane Permeation of a Cholesterol-Lowering Drug, Probucol
- Erectile dysfunction could be treated by a nanoparticle formulation applied directly to the penis